Proteintech beta Tubulin Mouse anti-C. elegans, Human, Mouse, Porcine, Rat, Zebrafish, Clone: 1D4A4, Proteintech

Mouse Monoclonal Antibody

Additional Details:
Additional Details: Weight: 0.00010kg



Product Code. 16837935

Quantity Price
1 189.0  € / 150µL
In stock, ready to ship: 6
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Description and Specification

Specification

Antigen beta Tubulin
Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Applications Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Classification Monoclonal
Clone 1D4A4
Concentration 1.43 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TUBB3
Gene Accession No. Q13509, Q4QRB4, Q9ERD7
Gene Alias beta tubulin, MC1R, TUBB, Tubulin-beta
Gene Symbols TUBB3
Host Species Mouse
Immunogen beta Tubulin Fusion Protein Ag0117
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102154194, 10381, 106509340, 22152, 246118
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Target Species C. elegans,Human,Mouse,Pig,Rat,Zebrafish
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintece. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.