Proteintech GAPDH Mouse anti-Human, Mouse, Plant, Rat, Yeast, Zebrafish, Clone: 1E6D9, Proteintech

Mouse Monoclonal Antibody

Additional Details:
Additional Details: Weight: 0.00010kg



Product Code. 16886955

Quantity Price
1 189.0  € / 150µL
In stock, ready to ship: 4
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Description and Specification

Specification

Antigen GAPDH
Applications Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation
Applications Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation
Applications Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation
Applications Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation
Applications Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation
Classification Monoclonal
Clone 1E6D9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene GAPDH
Gene Accession No. P04406, P04797, P16858, Q5XJ10
Gene Alias G3PD, GAPD, GAPDH, OK/SW cl.12
Gene Symbols gapdh
Host Species Mouse
Immunogen GAPDH Fusion Protein Ag0766
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14433, 24383, 2597, 317743
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Target Species Human,Mouse,Plant,Rat,Yeast,Zebrafish
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer′s disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington′s disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.