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Proteintech ZO-1 Rabbit anti-Canine, Hamster, Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Additional Details:
Additional Details: Weight: 0.00010kg



Product Code. 16891365

Quantity Price
1 145.0  € / 20µL
In stock, ready to ship: 5
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Description and Specification

Specification

Antigen ZO-1
Applications Immunocytochemistry,Immunoprecipitation,Immunofluorescence,Flow Cytometry,Western Blot
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TJP1
Gene Accession No. O97758, P39447, Q07157
Gene Alias Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, Zonula occludens protein 1
Gene Symbols TJP1
Host Species Rabbit
Immunogen ZO-1 Fusion Protein Ag16454
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100773110, 21872, 292994, 403752, 7082
Target Species Human,Canine,Hamster,Rat,Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.